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Assistance Publique – Hopitaux de Paris Robert Debré Hospital

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Assistance Publique Hôpitaux de Paris

Site 1: Robert Debré Hospital, Child and Adolescent Psychopathology Unit
48 bd Sérurier
75019 Paris

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Site 2: Groupe Hospitalier Pitié Salpêtrière, Child and Adolescent Psychiatry Department
48 bd de l’Hôpital
75013 Paris

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Site 3: Unit of Child and Adolescent Psychiatry.
Saint Eloi University Hospital Montpellier
34295 Montpellier

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Project leader

Pr Diane Purper-Ouakil, MD, PhD

Phone: +33 4 67 33 60 09
Fax: +33 1 40 03 22 97

Project staff Site 1

Dr Sara Bahadori, MD

Phone: +33 1 40 03 22 63
Fax: +33 1 40 03 22 97

Dr Isabelle Massat, MD, PhD
Joining the team Sept 2011

Phone: +33 1 40 03 22 63
Fax: +33 1 40 03 22 97

Dr Hugo Peyre, MD
Joining the team Nov 2011

Phone: +33 1 40 03 22 63
Fax: +33 1 40 03 22 97

Dr Alexandre Hubert, MD

Phone: +33 1 40 03 22 63
Fax: +33 1 40 03 22 97

Project staff Site 2

Pr David Cohen

Phone: +33 1 42 16 23 51
Website

Pr Olivier Bonnot

Phone: +33 1 42 16 23 51

Dr Julie Brunelle

Phone: +33 1 42 16 23 37
Fax: +33 1 42 16 23 31/23 50

Project staff Site 3

Nathalie Franc

Phone: +33 4 67 33 60 09

Florence Pupier

Phone: +33 4 67 33 60 09

Pierre Raysse

Phone: +33 4 67 33 60 09

Dr Stéphanie Legras

Phone: +33 4 67 33 60 09

Dr Martine Paradis

Phone: +33 4 67 33 60 09

Mme Cécile Vacher

Phone: +33 4 67 33 60 09

Philippe Gallula

Phone: +33 1 44 84 17 34
Fax: +33 1 44 84 17 01

Institute presentation

Site 1: Robert Debré Hospital, Child and Adolescent Psychopathology Unit, 48 bd Sérurier

The department of Child and Adolescent Psychiatry of the Robert Debré hospital in Paris is related to the Paris VII Lariboisière-Saint Louis University and to INSERM, both leading structures in medical research. As all Parisian university hospitals, the Robert Debré hospital belongs to the Assistance-Publique, the most important hospital consortium in France. It is entirely dedicated to pediatric care and offers specialized and emergency care for a large population (mainly north of Paris and region Ile de France).

The Child and Adolescent department, headed by Professor Marie Christine Mouren has extensive experience in pediatric clinical trials and psychopharmacology in children and adolescents. The department has two inpatient units (each of 12 beds), one evaluation unit for preschoolers, one evaluation unit for autistic disorders and several specialized outpatient facilities (learning disorders, ADHD, eating disorders, autism). An outpatient care unit is attached to the department for psychiatric community care for the XXth arrondissement of Paris.

Site 2: Groupe Hospitalier Pitié Salpêtrière, Child and Adolescent Psychiatry Department

The Department of Child and Adolescent Psychiatry of the Groupe Hospitalier Pitié-Salpétrière, headed by Professor David Cohen, is specialized in top-level clinical care and in research involving neuropsychiatric disorders such as Autism, Genetic syndromes with psychiatric phenotype, Mood disorders and Psychotic disorders. The research is embedded in two local research units, the Psychology and Cognitive Neurosciences Unit from the CNRS, and the Psychopharmacology Unit from the INSERM. As such, research into the efficacy and safety of medication treatment for psychiatric disorders in youths is on the priority list. The Pitié-Salpétrière child and adolescent psychiatry group is equipped with 50 inpatient beds distributed in 4 units and 3 day care units for 37 outpatients. Around 1500 new child and adolescent patients are consulting each year.

Site 3 information : MPEA St Eloi - Montpellier

The Child and Adolescent Unit of St Eloi University Hospital delivers general and specialized psychiatric services to young people living in Montpellier and its region. This unit has developed treatement programs and networks for adolescents with severe externalized and internalized behaviors and has dedicated day-clinics and inpatient facilities. The aim of this unit is the co-development of therapeutic innovation and clinical research projects such as STOP.

Research with relevance to the project:

  1. Consoli A, Deniau E, Huynh C, Purper D, Cohen D. Treatments in child and adolescent bipolar disorders. Eur Child Adolesc Psychiatry. 2007 Apr;16(3):187-98.
  2. Purper-Ouakil D, Cortese S, Wohl M, Asch M, Acquaviva E, Falissard B, Michel G, Mouren M, GorwoodP : Predictors of diagnostic delay in a clinical sample of French children with ADHD. Eur Child AdolescPsychiatry. 2007; 16 : 505-509
  3. Purper-Ouakil D, Wohl M, Orejarena S, Cortese S, Boni C, Asch M, Mouren MC, Gorwood P Pharmacogenetics of methylphenidate response in Attention Deficit/Hyperactivity Disorder : association with the dopamine transporter gene (SLC6A3). Am J Med Genet B Neuropsychiatr Genet. 2008; 147B(8):1425-30.
  4. Polanczyk G, Faraone SV, Bau CH, Victor MM, Becker K, Pelz R, Buitelaar JK, Franke B, Kooij S, van der Meulen E, Cheon KA, Mick E, Purper-Ouakil D, Gorwood P, Stein MA, Cook EH Jr, Rohde LA.The impact of individual and methodological factors in the variability of response to methylphenidate in ADHD pharmacogenetic studies from four different continents. Am J Med Genet B Neuropsychiatr Genet. 2008 Dec 5;147B(8):1419-24
  5. Asch M, Cortese S, Perez Diaz F, Pelissolo A, Aubron V, Orejarena S, Acquaviva E, Mouren MC, Michel G, Purper-Ouakil D. Psychometric properties of a French Parent-and Child-Rated Questionnaire adapted from the Junior Temperament and Character Inventory (JTCI). Eur J Child Adolesc Psychiatry. 2009; 18 : 144-53
  6. Ramoz N, Boni C, Downing AM, Close SL, Peters SL, Prokop AM, Allen AJ, Hamon M, Purper-Ouakil D, Gorwood P. A haplotype of the norepinephrine transporter (NET) gene SLC6A2 is associated with clinical response to atomoxetine in attention-deficit hyperactivity disorder (ADHD). Neuropsychopharmacology. 2009 Apr 22.
  7. Franc N, Purper-Ouakil D. ADHD medications and ethnicity. Current Attention Disorders Report. 2009; 1 (4) : 159-164. Online nov. 2009.
  8. Cohen D, Consoli A, Bodeau N, Purper-Ouakil D, Deniau E, Guile JM, Donnelly C. Predictors of placebo response in randomized controlled trials of psychotropic drugs for children and adolescents with internalizing disorders. Journal of Child and Adolescent Psychopharmacology. 2010; 20 : 39-47
  9. Purper-Ouakil D, Cortese S, Wohl M, Orejarena S, Aubron V, Michel G, Asch M, Mouren MC, Gorwood P. Temperament and character dimensions associated with clinical characteristics and treatment outcome in ADHD boys. Comprehensive Psychiatry 2010;51:286-92
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