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Centre for Paediatric Pharmacy Research, The School of Pharmacy, University of London, UK

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The Centre for Paediatric Pharmacy Research,
The School of Pharmacy, University of London,
BMA / Tavistock House,
Entrance A, 1st Floor,
Tavistock Square,
London,
WC1H 9JP.

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Project leader

Professor Ian Chi Kei Wong

Project staff

Dr. Macey Murray

Noha Iessa

Institute presentation

The School of Pharmacy is dedicated to teaching and research in pharmacy and pharmaceutics. Within the School of Pharmacy the Centre for Paediatric Pharmacy Research (CPPR) was established in April 2002 in collaboration with the Institute of Child Health and Great Ormond Street Hospital for Children. The aim of the Centre is to improve paediatric medicines, in particular, its quality, safety, efficacy and ethical policy. In addition, the specialist resources of universities and hospitals nationwide are utilised collaboratively to provide a focus for the training of health care professionals in the optimum use of medicines for children. It is the first center of its kind established in the UK.

Previous experience:

The Centre has a comprehensive expertise in paediatric drug safety and pharmacoepidemiology particularly in the area of paediatric neuropsychopharmacology. It has been conducting research in these areas since it was established in 2002. Prof Ian Wong and his team have been involved in many national and international collaborations either as principal applicant or UK-Coordinator such as the EU-commissioned “Task Force in Europe for Drug Development in the Young” (TEDDY) and the “Children and Adolescents Psychiatric pharmaco-Therapy Evaluation Research” (CHAPTER) or “Cessation of Attention deficit hyperactivity Disorder Drugs in Young” (CADDY) both funded by the Department of Health in England.

Profile of staff members:

Professor Ian Wong is Professor of Paediatric Pharmacy and Director of the Centre for Paediatric Pharmacy Research at the School of Pharmacy, University of London. He is the Chair of the Pharmacy and Pharmacology Clinical Study Group of the newly-formed Medicines for Children Research Network (MCRN) and the Coordinator of the Long-term Effects of Psychotropic Medication in Children Research Group of the Department of Health Mental Health Research Network. He has received the UK Department of Health Public Health Career Scientist Award obtained over £2.5 million in research grants as the principal applicant and approximately £8 million as a co-applicant. Prof Wong has published over 80 publications and is also working with pharmaceutical companies to conduct clinical trials studies for paediatric licensing applications.

Dr Macey Murray is a Senior Research Fellow, she has seven years’ experience of working in phase I-III clinical trials, from inception to the management of data for statistical analysis. She has worked for five years as a senior trial coordinator and data manager for an international phase III chemotherapy trial and six years’ experience in post-marketing surveillance of psychotropic medications in children and adolescents. She completed her PhD thesis on the epidemiology of antidepressant prescribing in young people.

Professor Frank Besag is a Consultant Neuropsychiatrist, and a visiting Clinical Professor at the School of Pharmacy. Honorary Consultant posts include Great Ormond Street Hospital for Children, King’s College and the Maudsley Hospitals, with Honorary Senior Lectureships at both Institutes of Psychiatry and Child Health. He was Medical Director of the National Centre for Young People with Epilepsy (formerly St Piers Lingfield), a special centre for young people with epilepsy, for over 10 years. He has over 60 publications in international journals and is the editor-in-chief of Current Drug Safety. Professor Besag has received research grants from the UK Medical Research Council, the British Epilepsy Research Foundation, the UK Medicines and Healthcare products Regulatory Agency, and pharmaceutical companies.

Research with relevance to the project:

  1. McCarthy S, Cranswick N, Potts L, Taylor E, Wong IC. Mortality associated with attention-deficit hyperactivity disorder (ADHD) drug treatment: a retrospective cohort study of children, adolescents and young adults using the general practice research database. Drug Safety 2009;32(11):1089-96.
  2. Hsia Y, Neubert A, Sturkenboom MC, Murray ML, Verhamme KM, Sen F, Giaquinto C, Ceci A, Wong IC; on behalf of the TEDDY Network of Excellence. Comparison of antiepileptic drug prescribing in children in three European countries. Epilepsia 2009 (epub Oct 9).
  3. Rani FA, Byrne PJ, Murray ML, Carter P, Wong IC. Paediatric Atypical antipsychotic Monitoring Safety (PAMS) Study: pilot study in children and adolescents in secondary- and tertiary-care settings. Drug Safety 2009;32(4):325-33.
  4. McCarthy S, Asherson P, Coghill D, Hollis C, Murray M, Potts L, Sayal K, de Soysa R, Taylor E, Williams T, Wong ICK. Attention-deficit hyperactivity disorder: treatment discontinuation in adolescents and young adults. British Journal of Psychiatry 2009;194:273-277.
  5. Rani F, Murray ML, Byrne PJ, Wong IC. Epidemiologic features of antipsychotic prescribing to children and adolescents in primary care in the United Kingdom. Pediatrics 2008;121(5):1002-1009.
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