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INSERM U669, paris-sud innovation group in adolescent mental health


Maison de Solenn
97 boulevard du Port royal
75679 Paris cedex 14


Project leader

Prof. Bruno Falissard

Prof. Bruno Falissard

Phone: +33 6818 270 76
Fax: +33 1584 128 43

Institute presentation

INSERM U669 (PSIGIAM: Paris-Sud innovation group in adolescent mental health) is a research unit dedicated to public health in mental health, especially at the adolescent age. It comprises 140 membres, mostly clinicians or epidemiologists. The three axes or research are: 1/ destructive behaviors (self or other), 2/ evaluation of treatments (mainly non pharmacologic), 3/ innovations in methodology

INSERM unit U669 has concentrated its research work on three lines of research: 1) research methodology in psychiatry; 2) evaluation of practices and care delivery in psychiatry; 3) harmful and self-harming behaviours (impulsivity, suicide, behavioural disorders, addictions, eating disorders, borderline personality, etc). The methodology was originally based on epidemiology. The present trend is to diversify, both in the direction of human sciences and in the direction of neuroscience.

Unit 669 has also formed an association with GRIP (Groupe de Recherche sur l'Inadaptation Psychosociale chez l'enfant, Montreal, headed by R. Tremblay) to form an international entity. GRIP is known worldwide for its numerous cohorts of children followed for durations of more than 20 years.

Previous experience:

INSERM unit U669 has published 350 papers indexed in pubmed in the last 4 years, with 4 papers in the Archives of General Psychiatry. 4 clinical trials on psychological interventions are presently ongoing (prevention of suicide attempts in borderline disorders, dependence to cannabis, prevention of conduct disorders, prevention of relapse in sexual abusers). Regular epidemiological studies (n=50000) are conducted each 4 years, dealing especially with substance use and abuse in adolescents.

Profile of staff members:

Prof. Falissard is Professor in Public health/Biostatistics at South Paris University, as well as Head of the Public Health Department of Paul Brousse Hospital since 1999. Prof. Falissard has been certified in Psychiatry in 1996, he received his PhD in Biostatistics in 1990 and his degree from the “Ecole Polytechnique” in Paris in 1985.

Since 2005, Prof. Falissard is also Head of INSERM U669 (PSIGIAM, Paris Sud Innovation Group in Adolescents Mental Health), a lab comprising of 90 members.

Prof. Falissard is a member of the scientific board of many foundations, as well as the board of the International Journal of Methods in Psychiatric Research and is Statistical advisor to the European Psychiatry journal. He is past president of the scientific board of “Faculté de Médecine Paris-Sud”.

Dr. Caroline Barry assists Prof. Falissard. Dr. Barry has a PhD in biology and a master in statistics. She has worked several years in a pharmaceutical firm and is presently research engineer in INSERM U669.

Research with relevance to the project:

  1. Short-Term Effectiveness of Medication and Psychosocial Intervention in a Cohort of Newly Diagnosed Patients With Inattention, Impulsivity, and Hyperactivity Problems. Falissard B, Coghill D, Rothenberger A, Lorenzo M. J Atten Disord. 2009 Sep 18.
  2. Psychometric characteristics of Cloninger's criteria for personality disorder in a population of French prisoners. Pelissolo A, Ecochard P, Falissard B. Int J Methods Psychiatr Res. 2008;17(1):30-4.
  3. The improved Clinical Global Impression Scale (iCGI): development and validation in depression. Kadouri A, Corruble E, Falissard B. BMC Psychiatry. 2007 Feb 6;7:7.
  4. The Adolescent Depression Rating Scale (ADRS): a validation study. Revah-Levy A, Birmaher B, Gasquet I, Falissard B. BMC Psychiatry. 2007 Jan 12;7:2.
  5. Outcome revealed by preference in schizophrenia (OPS): development of a new class of outcome measurements. Falissard B, Bazin N, Hardy-Bayle MC. Int J Methods Psychiatr Res. 2006;15(3):139-45.