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University College London, Institute of Child Health

Institute of Child Health
General and Adolescent Paediatrics Unit
30 Guilford Street
London  WC1N 1EH


Project leader

Dr Alastair G Sutcliffe

Dr Alastair G Sutcliffe

Phone: +44 (0)20 7905 2367
Fax: +44 (0)20 7905 2834

Project staff

Mr C White

Mr C White
PA/Unit Administrator

Phone: +44 (0)20 7905 2190
Fax: +44 (0)20 7905 2834

Institute presentation

UCL was ranked 4th in a recent world university ranking after Harvard, Cambridge and Yale. At any one time there are 250 EU funded research projects ongoing here. This included one previously led by the WP leader conducted in 5 European countries which was completed on time and on budget. The UCL Institute of Child Health, in partnership with Great Ormond Street Hospital, is the largest centre in Europe devoted to clinical and basic research and postgraduate teaching in children’s health.

Previous experience:

The Institute of Child Health is the base for SENCE-LRN. SENCE (South East North Central East) LRN (Local Research Network) is the national Medicines for Children Research Network local branch. It has a full team of research nurses and has a portfolio of over 70 clinical trials ongoing. One will be seconded to work on this study. We have access to a population of 1.1 million children, with associated hospitals within our network with access to others in the areas of London not covered by the network as needed. The WP leader led a major EU study looking at all aspects of the health of 1550 children aged 5 years conceived after assisted conception (ref QLRT-1999-30545) which was completed on time and on budget. The WP leader has prior experience of developing an online tool for monitoring children’s health. The tool which was funded by a department of health grant is an innovative quality of life measure for children aged 4 to 10 years. It can be viewed in draft form at www.wazdaka.com/silcworm.

Profile of staff members:

Alastair Sutcliffe (MD, PhD) is a consultant in general and adolescent paediatrics and Senior Lecturer in Child Health at the Institute of Child Health and honorary Senior Lecturer at School of Pharmacy. He is assistant director of SENCE-LRN and a principle contributor to the British National Formulary for Children. His present research projects include being a principle investigator on a national placebo randomised controlled trial to investigate the effects of melatonin on children aged 4 to 15 years’ sleep patterns. This trial has the acronym MENDS.

Caro Minasian (MD) is a consultant in respiratory paediatrics who trained at the Royal Brompton Hospital and works with Dr Sutcliffe at University College London Hospital. He helped advise about the asthma monitoring components of this work package and will be a key collaborator in liaising with the respiratory clinics involved throughput London. He will work on the project ‘gratis’.

Tracy Oakden (RN) registered sick children’s nurse works for Dr Sutcliffe on the MENDS trial. Her expertise in recruiting families, conducting visits and assessments will be essential in ensuring this WP happens on the ground.

Heather Hanna (RGN/RSCN) registered sick children’s nurse works for Dr Sutcliffe but is based at St Marys Hospital, Paddington, where the majority of the recruitment will take place. Her expertise in recruiting families, conducting visits and assessments will be essential in ensuring this WP happens on the ground.

Research with relevance to the project:

  1. Thomson SA, Tuleu C, Wong ICK, Keady S, Pitt KG, Sutcliffe AG. Minitablets: New modality to deliver medicines to preschool-aged children. Pediatrics. 2009 Feb; 123(2):e235-8.
  2. Shah T, Tse A, Gill H, Wong I, Sutcliffe A, Gringras P, Appleton R, Tuleu C. Administration of melatonin mixed with soft food and liquids for children with neurodevelopmental difficulties.Dev Med Child Neurol. 2008 Nov;50(11):845-9. Epub 2008 Aug 27.
  3. Sutcliffe AG, Wong IC. Rational prescribing for children. BMJ, 2006; 332: 1464-5.
  4. AG Sutcliffe, X Kantaris, M Shevlin, J Barnes, D Armstrong, D Nicholas, N Madge, D Christie. SILCWORM (Satisfaction in life for children with own report measures): A generic self scored measure of quality of life from the child under 10 years. Archives of Disease in Childhood 2008; 93 supplement 1: A112-114.