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University Medical Centre Groningen

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University Medical Center Groningen
Department of Child and Adolescent Psychiatry
Hanzeplein 1
9713 GZ Groningen

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Project leader

Dr. Pieter J. Hoekstra

Dr. Pieter J. Hoekstra

Phone: +31 50 36 81100
Fax: +31 50 36 81120

Project staff

Cora Drent

Cora Drent

Phone: +31 50 36 81100
Fax: +31 50 36 81120

Institute presentation

The University Medical Centre Groningen (UMCG) is a leading Dutch institute for medical research. The Department of Psychiatry and the Accare Child and Adolescent Psychiatry University Center (headed by Dr. Erik Mulder & Pieter J. Hoekstra) are specialized in top-level clinical care and research in neuropsychiatric disorders such as ADHD, Tourette’s Disorder, Schizophrenia, and Autism Spectrum Disorders. This research is embedded in an interdisciplinary research institute, the Graduate School of Behavioral and Cognitive Neurosciences. As such, research into the efficacy and safety of medication treatment for psychiatric disorders in children and adolescents is on the priority list. The Groningen child and adolescent psychiatry groups have access to over 4600 new child and adolescent patients per year. The clinical and research teams include a total of 25 child and adolescent psychiatrists, 20 senior psychologists, 5 post-docs and 20 trainees.

Previous experience:

The Department of Psychiatry of the UMCG has been involved in a number of collaborative studies including medication trials (e.g. Troost et al., 2005; and RADAR study), large epidemiological studies (see www.trails.nl) and NIH sponsored projects on the genetics of ADHD (International Multisite ADHD Genetics – IMAGE, R01MH62873 to Steve Faraone, P.I.). The former Head of the Groningen Child and Adolescent Psychiatry Centre (Ruud B. Minderaa) has been initiator and coordinator of the national Knowledge Centre for Child and Adolescent Psychiatry, involving all Dutch academic centres and a number of regional centres. The UMCG also has ample expertise in the management/coordination of FP7 Cooperative Projects.

Profile of staff members:

Pieter J. Hoekstra (MD, PhD) is child and adolescent psychiatrist and associate Professor at the Accare Child and Adolescent Psychiatry University Centre. He has been involved in a number of medication trials in children and adolescents with ADHD, Tic Disorders, and Autism Spectrum Disorder. He is further active in genetic, immunologic, and epidemiological studies.

Cora H. Drent (MANP, RN) is a Nurse Practitioner specialized in the pharmacotherapy of childhood developmental disorders.

Research with relevance to the project:

  1. Troost PW, Lahuis BE, Hermans MH, Buitelaar JK, van Engeland H, Scahill L, Minderaa RB, Hoekstra PJ. Prolactin release in children treated with risperidone: impact and role of CYP2D6 metabolism. J Clin Psychopharmacol. 2007 27(1):52-7.
  2. Troost PW, Steenhuis MP, Tuynman-Qua HG, Kalverdijk LJ, Buitelaar JK, Minderaa RB, Hoekstra PJ. Atomoxetine for attention-deficit/hyperactivity disorder symptoms in children with pervasive developmental disorders: a pilot study. J Child Adolesc Psychopharmacol. 2006 ;16(5):611-9.
  3. Troost PW, Althaus M, Lahuis BE, Buitelaar JK, Minderaa RB, Hoekstra PJ. Neuropsychological effects of risperidone in children with pervasive developmental disorders: a blinded discontinuation study. J Child Adolesc Psychopharmacol. 2006 16(5):561-73.
  4. Troost PW, Lahuis BE, Steenhuis MP, Ketelaars CE, Buitelaar JK, van Engeland H, Scahill L, Minderaa RB, Hoekstra PJ. Long-term effects of risperidone in children with autism spectrum disorders: a placebo discontinuation study. J Am Acad Child Adolesc Psychiatry. 2005 ;44(11):1137-44.
  5. van den Hoofdakker BJ, Nauta MH, Veen-Mulders LV, Sytema S, Emmelkamp PM, Minderaa RB, Hoekstra PJ. Behavioral Parent Training as an Adjunct to Routine Care in Children with Attention-Deficit/Hyperactivity Disorder: Moderators of Treatment Response. J Pediatr Psychol. 2009 24.
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